Procedure Skin Treatment : Facial and Body Our dermatologist will administer several tiny injections of BOTOX? Cosmetic directly into the muscles that cause those moderate to severe frown lines between the brows.  Our dermatologist will determine where to administer the injections by examining your ability to move certain muscles in your brow area. The location, size, and use of the muscles that create a furrowed brow vary markedly among individuals.  No anesthesia is required, although our dermatologist may choose to numb the area with a cold pack or anesthetic cream prior to injecting. Discomfort is usually minimal and brief.